This is the list of the main and supporting cast regulars of The Wayans Bros. TV series.
- Shawn Wayans - appears as Shawn Williams, at first a bike courier, then owner of Shawn's Newstand, located in the Niedermeyer Building's main lobby lives with Marlon in Manhattan, works at the newsstand located in the Niedermeyer Building's main lobby
- Marlon Waysns - appears as Marlon Williams, an aspiring actor, somewhat irresponsible (according to brother Shawn) lives with Shawn in a Manhattan apartment, works at first at Pop's Diner, then works for him at the newsstand located in the Niedermeyer Building's main lobby
- John Witherspoon - Appears as Pops Williams, a tacky-dressing owner of Pop's Diner located in the Niedermeyer Building near the newstand
- Anna Maria Horsford - appears as Dee Baxter the new security guard, beginning midway through season 2, staying with the cast for the duration of the serie's run
- Phill Lewis - appears as huckster Thelonious "T.C." Capricornio (season 2-5)
- Lela Rochon - appears as Lisa Saunders in season 1
- Ja'net Dubois - appears as Grandma Ellington in seasons 2-4 (1996–1998)
- Jermaine 'Huggy' Hopkins - appears as Dupree in seasons 2-4 (1996–1998)
- Paula Jai Parker - appeared as Monique Lattimore (season 2, episodes 1–11)
- Mitch Mullany - appears as White Mike in 6 episodes during seasons 1 and 2
- Jill Tasker - she appears as Lou Malino the security guard in season 2, episodes 1–7)
- Jeremy Hittel - Carwash (1996–1999)
- Lance Amols - Doc (1997–1999)
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