This is the list of the main and supporting chararters on The Wayans Bros. TV series.
- Shawn Williams - owner of the newstand located in the Niedemeyer Building's main lobby lives with Marlon in Manhattan, works at the newsstand located in the Niedemeyer Building's main lobby
- Marlon Williams - is an aspiring actor, is somewhat irresponsible (according to brother Shawn) lives with Shawn in a Manhattan apartment, works at the newsstand located in the Niedemeyer Building's main lobby
- John "Pops" Williams - a tacky-dressing owner of Pop's Diner located in the Niedemeyer Building near the newstand, excellet flamenco dancer
- Dee Baxter - buxom security guard, beginning midway through season 2, befriends the Williamses, always has man trouble, which T.C. tries to elleviate by making overtures towards her
- Thelonious "T.C." Capricornio, - a snazzy-dressing huckster friend of Marlon's who also befriends The Williamses, always hitting on disinterested Dee
- Grandma Ellington - Grandmother of Shawn and Marlon, Pop's mother-in-law, who appears in seasons 3 and 4
- Lisa Saunders - appears in season 1, works in the Niedemeyer Building, one time romantic interest of Shawn
- Monique Lattimore - appeared in season 2, episodes 1–11, also works in the building at a greeting card shop
- White Mike - hip-talking, black girl-dating White friend of Marlon who appears in seasons 1 and 2
- Lou Malino - she appears as the security guard in season 2, episodes 1–7)
- Dupree - appears sporadically in six episodes in seasons 4-5 (1997–1999)
- Benny - Cook at Pop's Diner appears sporadically in several episodes in seasons 1-2 (1995–1996)
- Carwash - appears sporadically in several episodes in seasons 2-5 (1996–1999)
- Doc - appears sporadically in several episodes in seasons 3-5 (1997–1999)
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